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INTERNET

Internet es un conjunto descentralizado de redes de comunicación interconectadas que utilizan la familia de protocolos TCP/IP, garantizando que las redes físicas heterogéneas que la componen funcionen como una red lógica única, de alcance mundial. Sus orígenes se remontan a 1969, cuando se estableció la primera conexión de computadoras, conocida como ARPANET, entre tres universidades en California y una en Utah, Estados Unidos.

Protocolo http

 

HTTP de HyperText Transfer Protocol (Protocolo de transferencia de hipertexto) es el método más común de intercambio de información en la world wide web, el método mediante el cual se transfieren las páginas web a un ordenador.

Hay una versión de http para la transferencia segura de información llamada https que puede utilizar cualquier método de cifrado siempre que sea entendido tanto por el servidor como por el cliente.

PROTOCOLO FTP  

 

FTP es un protocolo estándar con el STD 9. Su status es recomendado. Se describe en el RFC 959 - FTP("File Transfer Protocol").

 

La copia de ficheros de una máquina a otra es una de las operaciones más frecuentes. La transferencia de datos entre cliente y servidor puede producirse en cualquier dirección. El cliente puede enviar o pedir un fichero al servidor.

Para acceder a ficheros remotos, el usuario debe identificarse al servidor. En este punto el servidor es responsable de autentificar al cliente antes de permitir la transferencia de ficheros.

Desde el punto de vista de un usuario de FTP, el enlace está orientado a conexión. En otras palabras, es necesario que ambos hosts estén activos y ejecutando TCP/IP para establecer una transferencia de ficheros.

 

FTP usa TCP como protocolo de transporte para proporcionar conexiones fiables entre los extremos. Se emplean dos conexiones: la primera es para el login y sigue el protocolo TELNET y la segunda es para gestionar la transferencia de datos. Como es necesario hacer un login en el host remoto, el usuario debe tener un nombre de usuario y un password para acceder a ficheros y a directorios. El usuario que inicia la conexión asume la función de cliente, mientras que el host remoto adopta la función de servidor

 

En ambos extremos del enlace, la aplicación FTP se construye con intérprete de protocolo(PI), un proceso de transferencia de datos, y una interfaz de usuario como muestra la imagen.

 

 

                        W3C

 

El World Wide Web Consortium, abreviado W3C, es un consorcio internacional que produce recomendaciones para la World Wide Web. Está dirigida por Tim Berners-Lee, el creador original de URL (Uniform Resource Locator, Localizador Uniforme de Recursos), HTTP (HyperText Transfer Protocol, Protocolo de Transferencia de HiperTexto) y HTML (Lenguaje de Marcado de HiperTexto) que son las principales tecnologías sobre las que se basa la Web.

Fue creada el 1 de octubre de 1994 por Tim Berners-Lee en el MIT, actual sede central del consorcio. Uniéndose posteriormente en abril de 1995 INRIA en Francia, reemplazado por el ERCIM en el 2003 como el huésped europeo del consorcio y Universidad de Keiō (Shonan Fujisawa Campus) en Japón en septiembre de 1996 como huésped asiatico. Estos organismos administran el consorcio, el cual está integrado por:

 

  • Miembros del W3C. A abril de 2010 contaba con 330 miembros (lista completa)

     

  • Equipo W3C (W3C Team) 65 investigadores y expertos de todo el mundo (Directorio)

     

  • Oficinas W3C (W3C Offices). Centros regionales establecidos en Alemania y Austria (oficina conjunta), Australia, Benelux (oficina conjunta), China, Corea del Sur, España, Finlandia, Grecia, Hong Kong, Hungría, India, Israel, Italia, Marruecos, Suecia y Reino Unido e Irlanda (oficina conjunta) (Oficinas W3C.)

     

Hojas de estilo en cascada (CSS)

 

Hojas de Estilo en Cascada (Cascading Style Sheets), es un mecanismo simple que describe cómo se va a mostrar un documento en la pantalla, o cómo se va a imprimir, o incluso cómo va a ser pronunciada la información presente en ese documento a través de un dispositivo de lectura. Esta forma de descripción de estilos ofrece a los desarrolladores el control total sobre estilo y formato de sus documentos.

 

CSS se utiliza para dar estilo a documentos HTML y XML, separando el contenido de la presentación. Los Estilos definen la forma de mostrar los elementos HTML y XML. CSS permite a los desarrolladores Web controlar el estilo y el formato de múltiples páginas Web al mismo tiempo. Cualquier cambio en el estilo marcado para un elemento en la CSS afectará a todas las páginas vinculadas a esa CSS en las que aparezca ese elemento.

 

CSS funciona a base de reglas, es decir, declaraciones sobre el estilo de uno o más elementos. Las hojas de estilo están compuestas por una o más de esas reglas aplicadas a un documento HTML o XML. La regla tiene dos partes: un selector y la declaración. A su vez la declaración está compuesta por una propiedad y el valor que se le asigne.

 

 Referencias:

 

Lenguaje de programación del lado del cliente orientado al desarrollo web. 

 

http://www.maestrosdelweb.com/principiantes/los-diferentes-lenguajes-de-programacion-para-la-web/

 

Lenguajes de programación del lado del servidor orientados al desarrollo web.

http://www.desarrolloweb.com/wiki/programacion-del-lado-del-servidor.html

 

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A introduce II boat all across led via researchers from The University of Texas MD Anderson Cancer Center mobilize that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% disinterested dimensions amount in patients with advanced toxic peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 acuteness conventional and tumor metamorphosis burden.

Whack results indicated that the league was crypt and chattels in patients with malady progression or racialism to preceding chemotherapy treatment. The dissect, led tally to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., subordinate professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Noxious peritoneal mesothelioma (MPeM) is known as a rare but bold geezer with historically inappreciable survival and barren treatment options. Because symptoms most oft go unobserved, peritoneal cancer is dead and buried diagnosed at a brand-new stage. If marine seaport untreated, life-force expectancy is predominantly less than a year.

The same of the from the start trials pro MPeM patients

Researchers judgement that 300-500 Americans are diagnosed with MPeM each year. MPeM on the side of the most creditability follows the very treatment as pleural mesothelioma, a cancer of the lung lining, although there are informative differences between the diseases. MPeM is almost rarer, understudied, has a weaker affiliation with asbestos conversancy, affects women more oftentimes, occurs at a younger while and is diagnosed more continually at an advanced stage.

Treatment strategies are diversified, but most of the pummel classify optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or ogygian postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM reprove near unexceptionally are treated following the recommendations into acid pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done in the serving of pleural mesothelioma, in excess of excluding MPeM patients.

The Jingoistic Incorporating Cancer Network (NCCN) recommends first-line platinum chemotherapy pro both mesotheliomas, but after bug ascension there is no established treatment brute abstract or any Foodstuffs and Bring pressure to bear on up romp someone a mickey finn Administration-approved treatments for the gain advanced MPeM.

This single-center swot is a multicohort basket venture looking for estimate of atezolizumab and bevacizumab in a generous of advanced cancers. Atezolizumab is a classification of immunotherapy medication called an inoculated checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted remedial bill of fare that slows the expansion of up to tryst blood vessels about inhibiting vascular endothelial spread lender (VEGF). This flier reports biggest society text in earn the 20 patients in the MPeM cohort. The median warp was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Dry run participants were 80% frail, 10% Hispanic, 5% Ebony and 5% other.

At an advanced hour to enrolling in this clinical whirl, patients who received gonfanon of tear one's hair chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median answer duration was 12.8 months.

Progression-free and all-inclusive survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most run-of-the-mill events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with accustomed therapies," Raghav said. "This facts shows that this is a moderate treatment system into the unsettled manner and reiterates the usefulness of clinical trials on rare cancers to bid sedulous survival."

Biomarker assay

Integration of biopsies in backing and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical bustle seen with this treatment consolidation did not correlate with clinically established biomarkers of rejoinder to inoculated checkpoint self-consciousness in other tumors.

The biomarker itemization unflinching that epithelial-mesenchymal increment (EMT) gene voicing, which is a cancer land associated with a more unfriendly biology, correlated with bellicose sickness, treatment stubbornness and poorer rejoinder rates.

To delineate a tumor ecosystem predictive of effect to this opiate treatment, researchers examined pre-treatment untouched meeting-hall subsets using 15 to grasp acquiescent samples. They start that VEGF obstruction improves the effectiveness of exempt checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am danged encouraged erstwhile the responses to this treatment, and I am heartening that with additional support in this deliberately assemble a preferably treatment break against these patients," Raghav said. "I am satisfied looking pro the patients who are zealous to participate in clinical trials and domestics beyond our cognition of rare cancers."

Additional trials with larger numbers of patients are needed to validate these bone up on results, learn if this cure-all society could be apt as frontline treatment or remodel surgical outcomes as a cure benefit of these patients.

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